Vagal nerve stimulation for epilepsy and depression
Vagal, or vagus, nerve stimulation (VNS) is a neuromodulatory therapy that sends electric signals to the brain. A small device, called a pulse generator, is implanted into the left side of the chest to produce repeating, low-level pulses of electrical current along the vagus nerve to the brain.
Status: Decision completed
Why is VNS being reviewed?
Concerns about safety, efficacy and costs regarding whether vagal nerve stimulation (VNS) provides adequate treatment for epilepsy and depression. VNS has been shown to affect blood flow to different parts of the brain, and affect neurotransmitters which are implicated in depression. Important clinical questions remain, especially around the efficacy of using of VNS to treat epilepsy and depression.
Primary criteria ranking
- Safety = High
- Efficacy = High
- Cost = High
|Update literature (2013)|
Assessment timeline (2020)
- Draft key questions published: October 16, 2019
- Public comment period: October 16 to 29, 2019
- Final key questions published: November 18, 2019
- Draft report published: February 26, 2020
- Public comment period: February 27 to March 30, 2020
- Final report published: April 13, 2020
- HTCC public meeting: May 15, 2020