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Vagal nerve stimulation for epilepsy and depression
Vagal nerve stimulation (VNS) for epilepsy and depression was first reviewed by the HTA in 2009.
- In 2013, a review of VNS medical literature was conducted to determine if newly available evidence published since 2008 was likely to change the original coverage determination. The technology was not selected for re-review.
- In 2019, the HCA director selected VNS for re-review based on newly available evidence published since the 2009 assessment which could change the original coverage determination.
- A re-review of vagal nerve stimulation for epilepsy and depression is now in process.
Concerns about safety, efficacy and costs regarding whether vagal nerve stimulation (VNS) provides adequate treatment for epilepsy and depression. VNS has been shown to affect blood flow to different parts of the brain, and affect neurotransmitters which are implicated in depression. Important clinical questions remain, especially around the efficacy of using of VNS to treat epilepsy and depression.
Primary criteria ranking
- Safety = High
- Efficacy = High
- Cost = High
Assessment (now in process)
- Draft key questions: comment and response (11/18/19)
- Final key questions (11/18/19)
- Draft evidence report (02/26/20)
- Draft evidence report: appendix g - MAUDE and medical device recall reports (02/26/20)
- Draft evidence report: appendix j - excluded studies (02/26/20)
Update literature (2013)
Assessment timeline (2020)
- Draft key questions published: October 16, 2019
- Public comment period: October 16 to 29, 2019
- Final key questions published: November 18, 2019
- Draft report published: February 26, 2020
- Public comment period: February 27 to March 30, 2020
- Final report published: April 14, 2020
- HTCC public meeting: May 15, 2020