Vagal nerve stimulation for epilepsy and depression
Vagal nerve stimulation (VNS) for epilepsy and depression was first reviewed by the HTA in 2009.
- In 2013, a review of VNS medical literature was conducted to determine if newly available evidence published since 2008 was likely to change the original coverage determination. The technology was not selected for re-review.
- In 2019, the HCA director selected VNS for re-review based on newly available evidence published since the 2009 assessment which could change the original coverage determination.
- A re-review of vagal nerve stimulation for epilepsy and depression is now pending.
Concerns about safety, efficacy and costs regarding whether vagal nerve stimulation (VNS) provides adequate treatment for epilepsy and depression. VNS has been shown to affect blood flow to different parts of the brain, and affect neurotransmitters which are implicated in depression. Important clinical questions remain, especially around the efficacy of using of VNS to treat epilepsy and depression.
Primary criteria ranking
- Safety = High
- Efficacy = High
- Cost = High
Assessment timeline (2009)
- Draft evidence report published: July 10, 2009
- Public comment period: July 10 to 24, 2009
- Final evidence report published: July 31, 2009
- HTCC public meeting: August 28, 2009