Treatments for chondral defects of the knee
Treatments to include in review for patients with chondral defects of the knee would be matrix-induced autologous chondrocyte implantation (MACI), autologous chondrocyte implantation (ACI), microfracture surgery, and osteochondral autologous transplantation (OATS) as potential alternatives to surgical knee cartilage repair strategy.
Status: Review in progress
Why are treatments for chondral defects being reviewed?
Significant questions remain about the safety, efficacy, and effectiveness, and cost effectiveness of OATS/mosaicplasty cartilage surgery, MACI, ACI, and microfracture surgery.
Primary criteria ranking
- Safety = High
- Efficacy = Medium
- Cost = High
Documentation
Type | Materials |
---|---|
Assessment (2024) | |
Update literature for OATS (2018) | |
Assessment on OATS (2011) |
Assessment timeline
- Draft key questions published: December 22, 2023
- Public comment period: December 22, 2023 to January 5, 2024
- Final key questions published: January 22, 2024
- Draft report published: June 28, 2024
- Public comment period: June 28 to July 27, 2024
- Final report published: August 23, 2024
- HTCC public meeting: September 20, 2024
- Draft findings and decision published: September 30, 2024
- Public comment period: September 30 to October 14, 2024
- Final findings and decision published: November 27, 2024
All future dates are estimates and subject to change.